Tuberculosis and other opportunistic infections in tofacitinib-treated patients with rheumatoid arthritis
Identifieur interne : 000105 ( Main/Exploration ); précédent : 000104; suivant : 000106Tuberculosis and other opportunistic infections in tofacitinib-treated patients with rheumatoid arthritis
Auteurs : K L Winthrop [États-Unis] ; S-H Park [Corée du Sud] ; A. Gul [Turquie] ; M H Cardiel [Mexique] ; J J Gomez-Reino [Espagne] ; Y. Tanaka [Japon] ; K. Kwok [États-Unis] ; T. Lukic [États-Unis] ; E. Mortensen [États-Unis] ; D. Ponce De Leon [Pérou] ; R. Riese [États-Unis] ; H. Valdez [États-Unis]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2015.
Abstract
To evaluate the risk of opportunistic infections (OIs) in patients with rheumatoid arthritis (RA) treated with tofacitinib.
Phase II, III and long-term extension clinical trial data (April 2013 data-cut) from the tofacitinib RA programme were reviewed. OIs defined a priori included mycobacterial and fungal infections, multidermatomal herpes zoster and other viral infections associated with immunosuppression. For OIs, we calculated crude incidence rates (IRs; per 100 patient-years (95% CI)); for tuberculosis (TB) specifically, we calculated rates stratified by patient enrolment region according to background TB IR (per 100 patient-years): low (≤0.01), medium (>0.01 to ≤0.05) and high (>0.05).
We identified 60 OIs among 5671 subjects; all occurred among tofacitinib-treated patients. TB (crude IR 0.21, 95% CI of (0.14 to 0.30)) was the most common OI (n=26); median time between drug start and diagnosis was 64 weeks (range 15–161 weeks). Twenty-one cases (81%) occurred in countries with high background TB IR, and the rate varied with regional background TB IR: low 0.02 (0.003 to 0.15), medium 0.08 (0.03 to 0.21) and high 0.75 (0.49 to 1.15). In Phase III studies, 263 patients diagnosed with latent TB infection were treated with isoniazid and tofacitinib concurrently; none developed TB. For OIs other than TB, 34 events were reported (crude IR 0.25 (95% CI 0.18 to 0.36)).
Within the global tofacitinib RA development programme, TB was the most common OI reported but was rare in regions of low and medium TB incidence. Patients who screen positive for latent TB can be treated with isoniazid during tofacitinib therapy.
Url:
DOI: 10.1136/annrheumdis-2015-207319
PubMed: 26318385
PubMed Central: 4893093
Affiliations:
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Gul</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Istanbul Faculty of Medicine</addr-line>,<institution>Istanbul University</institution>,<addr-line>Istanbul</addr-line>,<country>Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cardiel, M H" sort="Cardiel, M H" uniqKey="Cardiel M" first="M H" last="Cardiel">M H Cardiel</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Centro de Investigación Clínica de Morelia SC</institution>,<addr-line>Morelia</addr-line>,<country>Mexico</country></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gomez Reino, J J" sort="Gomez Reino, J J" uniqKey="Gomez Reino J" first="J J" last="Gomez-Reino">J J Gomez-Reino</name><affiliation wicri:level="1"><nlm:aff id="af5"><institution>Hospital Clínico Universitario de Santiago</institution>,<addr-line>Santiago de Compostela</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tanaka, Y" sort="Tanaka, Y" uniqKey="Tanaka Y" first="Y" last="Tanaka">Y. Tanaka</name><affiliation wicri:level="1"><nlm:aff id="af6"><institution>University of Occupational and Environmental Health</institution>,<addr-line>Kitakyushu</addr-line>,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kwok, K" sort="Kwok, K" uniqKey="Kwok K" first="K" last="Kwok">K. Kwok</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Pfizer Inc</institution>,<addr-line>New York, New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lukic, T" sort="Lukic, T" uniqKey="Lukic T" first="T" last="Lukic">T. Lukic</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Pfizer Inc</institution>,<addr-line>New York, New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mortensen, E" sort="Mortensen, E" uniqKey="Mortensen E" first="E" last="Mortensen">E. Mortensen</name><affiliation wicri:level="1"><nlm:aff id="af8"><institution>Pfizer Inc</institution>,<addr-line>Collegeville</addr-line>, Pennsylvania,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ponce De Leon, D" sort="Ponce De Leon, D" uniqKey="Ponce De Leon D" first="D" last="Ponce De Leon">D. Ponce De Leon</name><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Pfizer Inc</institution>,<addr-line>Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Riese, R" sort="Riese, R" uniqKey="Riese R" first="R" last="Riese">R. Riese</name><affiliation wicri:level="1"><nlm:aff id="af10"><institution>Pfizer Inc</institution>,<addr-line>Groton</addr-line>, Connecticut,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Valdez, H" sort="Valdez, H" uniqKey="Valdez H" first="H" last="Valdez">H. Valdez</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Pfizer Inc</institution>,<addr-line>New York, New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26318385</idno><idno type="pmc">4893093</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893093</idno><idno type="RBID">PMC:4893093</idno><idno type="doi">10.1136/annrheumdis-2015-207319</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000081</idno><idno type="wicri:Area/Pmc/Curation">000081</idno><idno type="wicri:Area/Pmc/Checkpoint">000082</idno><idno type="wicri:Area/Ncbi/Merge">000342</idno><idno type="wicri:Area/Ncbi/Curation">000342</idno><idno type="wicri:Area/Ncbi/Checkpoint">000342</idno><idno type="wicri:doubleKey">0003-4967:2015:Winthrop K:tuberculosis:and:other</idno><idno type="wicri:Area/Main/Merge">000105</idno><idno type="wicri:Area/Main/Curation">000105</idno><idno type="wicri:Area/Main/Exploration">000105</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Tuberculosis and other opportunistic infections in tofacitinib-treated patients with rheumatoid arthritis</title><author><name sortKey="Winthrop, K L" sort="Winthrop, K L" uniqKey="Winthrop K" first="K L" last="Winthrop">K L Winthrop</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Oregon Health and Science University</institution>,<addr-line>Portland, Oregon</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Park, S H" sort="Park, S H" uniqKey="Park S" first="S-H" last="Park">S-H Park</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Rheumatology, Department of Internal Medicine</addr-line>,<institution>Seoul St. Mary's Hospital, The Catholic University of Korea</institution>,<addr-line>Seoul</addr-line>,<country>South Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gul, A" sort="Gul, A" uniqKey="Gul A" first="A" last="Gul">A. Gul</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Istanbul Faculty of Medicine</addr-line>,<institution>Istanbul University</institution>,<addr-line>Istanbul</addr-line>,<country>Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cardiel, M H" sort="Cardiel, M H" uniqKey="Cardiel M" first="M H" last="Cardiel">M H Cardiel</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Centro de Investigación Clínica de Morelia SC</institution>,<addr-line>Morelia</addr-line>,<country>Mexico</country></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gomez Reino, J J" sort="Gomez Reino, J J" uniqKey="Gomez Reino J" first="J J" last="Gomez-Reino">J J Gomez-Reino</name><affiliation wicri:level="1"><nlm:aff id="af5"><institution>Hospital Clínico Universitario de Santiago</institution>,<addr-line>Santiago de Compostela</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tanaka, Y" sort="Tanaka, Y" uniqKey="Tanaka Y" first="Y" last="Tanaka">Y. Tanaka</name><affiliation wicri:level="1"><nlm:aff id="af6"><institution>University of Occupational and Environmental Health</institution>,<addr-line>Kitakyushu</addr-line>,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kwok, K" sort="Kwok, K" uniqKey="Kwok K" first="K" last="Kwok">K. Kwok</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Pfizer Inc</institution>,<addr-line>New York, New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lukic, T" sort="Lukic, T" uniqKey="Lukic T" first="T" last="Lukic">T. Lukic</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Pfizer Inc</institution>,<addr-line>New York, New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mortensen, E" sort="Mortensen, E" uniqKey="Mortensen E" first="E" last="Mortensen">E. Mortensen</name><affiliation wicri:level="1"><nlm:aff id="af8"><institution>Pfizer Inc</institution>,<addr-line>Collegeville</addr-line>, Pennsylvania,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ponce De Leon, D" sort="Ponce De Leon, D" uniqKey="Ponce De Leon D" first="D" last="Ponce De Leon">D. Ponce De Leon</name><affiliation wicri:level="1"><nlm:aff id="af9"><institution>Pfizer Inc</institution>,<addr-line>Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Riese, R" sort="Riese, R" uniqKey="Riese R" first="R" last="Riese">R. Riese</name><affiliation wicri:level="1"><nlm:aff id="af10"><institution>Pfizer Inc</institution>,<addr-line>Groton</addr-line>, Connecticut,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Valdez, H" sort="Valdez, H" uniqKey="Valdez H" first="H" last="Valdez">H. Valdez</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Pfizer Inc</institution>,<addr-line>New York, New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of the Rheumatic Diseases</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>To evaluate the risk of opportunistic infections (OIs) in patients with rheumatoid arthritis (RA) treated with tofacitinib.</p></sec><sec><title>Methods</title><p>Phase II, III and long-term extension clinical trial data (April 2013 data-cut) from the tofacitinib RA programme were reviewed. OIs defined a priori included mycobacterial and fungal infections, multidermatomal herpes zoster and other viral infections associated with immunosuppression. For OIs, we calculated crude incidence rates (IRs; per 100 patient-years (95% CI)); for tuberculosis (TB) specifically, we calculated rates stratified by patient enrolment region according to background TB IR (per 100 patient-years): low (≤0.01), medium (>0.01 to ≤0.05) and high (>0.05).</p></sec><sec><title>Results</title><p>We identified 60 OIs among 5671 subjects; all occurred among tofacitinib-treated patients. TB (crude IR 0.21, 95% CI of (0.14 to 0.30)) was the most common OI (n=26); median time between drug start and diagnosis was 64 weeks (range 15–161 weeks). Twenty-one cases (81%) occurred in countries with high background TB IR, and the rate varied with regional background TB IR: low 0.02 (0.003 to 0.15), medium 0.08 (0.03 to 0.21) and high 0.75 (0.49 to 1.15). In Phase III studies, 263 patients diagnosed with latent TB infection were treated with isoniazid and tofacitinib concurrently; none developed TB. For OIs other than TB, 34 events were reported (crude IR 0.25 (95% CI 0.18 to 0.36)).</p></sec><sec><title>Conclusions</title><p>Within the global tofacitinib RA development programme, TB was the most common OI reported but was rare in regions of low and medium TB incidence. Patients who screen positive for latent TB can be treated with isoniazid during tofacitinib therapy.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Novosad, Sa" uniqKey="Novosad S">SA Novosad</name></author><author><name sortKey="Winthrop, Kl" uniqKey="Winthrop K">KL Winthrop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramiro, S" uniqKey="Ramiro S">S Ramiro</name></author><author><name sortKey="Gaujoux Viala, C" uniqKey="Gaujoux Viala C">C Gaujoux-Viala</name></author><author><name sortKey="Nam, Jl" uniqKey="Nam J">JL Nam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jick, Ss" uniqKey="Jick S">SS Jick</name></author><author><name sortKey="Lieberman, Es" uniqKey="Lieberman E">ES Lieberman</name></author><author><name sortKey="Rahman, Mu" uniqKey="Rahman M">MU Rahman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winthrop, Kl" uniqKey="Winthrop K">KL Winthrop</name></author><author><name sortKey="Iseman, M" uniqKey="Iseman M">M Iseman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deepe, Gs" uniqKey="Deepe G">GS Deepe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wallis, Rs" uniqKey="Wallis R">RS Wallis</name></author><author><name sortKey="Broder, M" uniqKey="Broder M">M Broder</name></author><author><name sortKey="Wong, J" uniqKey="Wong J">J Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wallis, Rs" uniqKey="Wallis R">RS Wallis</name></author><author><name sortKey="Broder, Ms" uniqKey="Broder M">MS Broder</name></author><author><name sortKey="Wong, Jy" uniqKey="Wong J">JY Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marino, S" uniqKey="Marino S">S Marino</name></author><author><name sortKey="Sud, D" uniqKey="Sud D">D Sud</name></author><author><name sortKey="Plessner, H" uniqKey="Plessner H">H Plessner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winthrop, Kl" uniqKey="Winthrop K">KL Winthrop</name></author><author><name sortKey="Chiller, T" uniqKey="Chiller T">T Chiller</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, Dm" uniqKey="Meyer D">DM Meyer</name></author><author><name sortKey="Jesson, Mi" uniqKey="Jesson M">MI Jesson</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kremer, Jm" uniqKey="Kremer J">JM Kremer</name></author><author><name sortKey="Cohen, S" uniqKey="Cohen S">S Cohen</name></author><author><name sortKey="Wilkinson, Be" uniqKey="Wilkinson B">BE Wilkinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kremer, Jm" uniqKey="Kremer J">JM Kremer</name></author><author><name sortKey="Bloom, Bj" uniqKey="Bloom B">BJ Bloom</name></author><author><name sortKey="Breedveld, Fc" uniqKey="Breedveld F">FC Breedveld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fleischmann, R" uniqKey="Fleischmann R">R Fleischmann</name></author><author><name sortKey="Cutolo, M" uniqKey="Cutolo M">M Cutolo</name></author><author><name sortKey="Genovese, Mc" uniqKey="Genovese M">MC Genovese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanaka, Y" uniqKey="Tanaka Y">Y Tanaka</name></author><author><name sortKey="Suzuki, M" uniqKey="Suzuki M">M Suzuki</name></author><author><name sortKey="Nakamura, H" uniqKey="Nakamura H">H Nakamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanaka, Y" uniqKey="Tanaka Y">Y Tanaka</name></author><author><name sortKey="Takeuchi, T" uniqKey="Takeuchi T">T Takeuchi</name></author><author><name sortKey="Yamanaka, H" uniqKey="Yamanaka H">H Yamanaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcinnes, Ib" uniqKey="Mcinnes I">IB McInnes</name></author><author><name sortKey="Kim, Hy" uniqKey="Kim H">HY Kim</name></author><author><name sortKey="Lee, Sh" uniqKey="Lee S">SH Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burmester, Gr" uniqKey="Burmester G">GR Burmester</name></author><author><name sortKey="Panaccione, R" uniqKey="Panaccione R">R Panaccione</name></author><author><name sortKey="Gordon, Kb" uniqKey="Gordon K">KB Gordon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kremer, J" uniqKey="Kremer J">J Kremer</name></author><author><name sortKey="Li, Zg" uniqKey="Li Z">ZG Li</name></author><author><name sortKey="Hall, S" uniqKey="Hall S">S Hall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fleischmann, R" uniqKey="Fleischmann R">R Fleischmann</name></author><author><name sortKey="Kremer, J" uniqKey="Kremer J">J Kremer</name></author><author><name sortKey="Cush, J" uniqKey="Cush J">J Cush</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Heijde, D" uniqKey="Van Der Heijde D">D van der Heijde</name></author><author><name sortKey="Tanaka, Y" uniqKey="Tanaka Y">Y Tanaka</name></author><author><name sortKey="Fleischmann, R" uniqKey="Fleischmann R">R Fleischmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Vollenhoven, Rf" uniqKey="Van Vollenhoven R">RF van Vollenhoven</name></author><author><name sortKey="Fleischmann, R" uniqKey="Fleischmann R">R Fleischmann</name></author><author><name sortKey="Cohen, S" uniqKey="Cohen S">S Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Eb" uniqKey="Lee E">EB Lee</name></author><author><name sortKey="Fleischmann, R" uniqKey="Fleischmann R">R Fleischmann</name></author><author><name sortKey="Hall, S" uniqKey="Hall S">S Hall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wollenhaupt, J" uniqKey="Wollenhaupt J">J Wollenhaupt</name></author><author><name sortKey="Silverfield, J" uniqKey="Silverfield J">J Silverfield</name></author><author><name sortKey="Lee, Eb" uniqKey="Lee E">EB Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamanaka, H" uniqKey="Yamanaka H">H Yamanaka</name></author><author><name sortKey="Tanaka, Y" uniqKey="Tanaka Y">Y Tanaka</name></author><author><name sortKey="Takeuchi, T" uniqKey="Takeuchi T">T Takeuchi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Greenberg, Jd" uniqKey="Greenberg J">JD Greenberg</name></author><author><name sortKey="Reed, G" uniqKey="Reed G">G Reed</name></author><author><name sortKey="Kremer, Jm" uniqKey="Kremer J">JM Kremer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dixon, Wg" uniqKey="Dixon W">WG Dixon</name></author><author><name sortKey="Watson, K" uniqKey="Watson K">K Watson</name></author><author><name sortKey="Lunt, M" uniqKey="Lunt M">M Lunt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salmon Ceron, D" uniqKey="Salmon Ceron D">D Salmon-Ceron</name></author><author><name sortKey="Tubach, F" uniqKey="Tubach F">F Tubach</name></author><author><name sortKey="Lortholary, O" uniqKey="Lortholary O">O Lortholary</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winthrop, Kl" uniqKey="Winthrop K">KL Winthrop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carmona, L" uniqKey="Carmona L">L Carmona</name></author><author><name sortKey="Gomez Reino, Jj" uniqKey="Gomez Reino J">JJ Gomez-Reino</name></author><author><name sortKey="Rodriguez Valverde, V" uniqKey="Rodriguez Valverde V">V Rodriguez-Valverde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Askling, J" uniqKey="Askling J">J Askling</name></author><author><name sortKey="Fored, Cm" uniqKey="Fored C">CM Fored</name></author><author><name sortKey="Brandt, L" uniqKey="Brandt L">L Brandt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolfe, F" uniqKey="Wolfe F">F Wolfe</name></author><author><name sortKey="Michaud, K" uniqKey="Michaud K">K Michaud</name></author><author><name sortKey="Anderson, J" uniqKey="Anderson J">J Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winthrop, K" uniqKey="Winthrop K">K Winthrop</name></author><author><name sortKey="Baxter, R" uniqKey="Baxter R">R Baxter</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arkema, Ev" uniqKey="Arkema E">EV Arkema</name></author><author><name sortKey="Jonsson, J" uniqKey="Jonsson J">J Jonsson</name></author><author><name sortKey="Baecklund, E" uniqKey="Baecklund E">E Baecklund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tubach, F" uniqKey="Tubach F">F Tubach</name></author><author><name sortKey="Salmon, D" uniqKey="Salmon D">D Salmon</name></author><author><name sortKey="Ravaud, P" uniqKey="Ravaud P">P Ravaud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsia, Ec" uniqKey="Hsia E">EC Hsia</name></author><author><name sortKey="Cush, Jj" uniqKey="Cush J">JJ Cush</name></author><author><name sortKey="Matteson, El" uniqKey="Matteson E">EL Matteson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Acevedo Vasquez, E" uniqKey="Acevedo Vasquez E">E Acevedo-Vasquez</name></author><author><name sortKey="Ponce De Leon, D" uniqKey="Ponce De Leon D">D Ponce de Leon</name></author><author><name sortKey="Gamboa Cardena, R" uniqKey="Gamboa Cardena R">R Gamboa-Cardena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winthrop, Kl" uniqKey="Winthrop K">KL Winthrop</name></author><author><name sortKey="Weinblatt, Me" uniqKey="Weinblatt M">ME Weinblatt</name></author><author><name sortKey="Daley, Cl" uniqKey="Daley C">CL Daley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wallis, Rs" uniqKey="Wallis R">RS Wallis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winthrop, Kl" uniqKey="Winthrop K">KL Winthrop</name></author><author><name sortKey="Yamashita, S" uniqKey="Yamashita S">S Yamashita</name></author><author><name sortKey="Beekmann, Se" uniqKey="Beekmann S">SE Beekmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dixon, Wg" uniqKey="Dixon W">WG Dixon</name></author><author><name sortKey="Hyrich, Kl" uniqKey="Hyrich K">KL Hyrich</name></author><author><name sortKey="Watson, Kd" uniqKey="Watson K">KD Watson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winthrop, Kl" uniqKey="Winthrop K">KL Winthrop</name></author><author><name sortKey="Baxter, R" uniqKey="Baxter R">R Baxter</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winthrop, Kl" uniqKey="Winthrop K">KL Winthrop</name></author><author><name sortKey="Calabrese, Lh" uniqKey="Calabrese L">LH Calabrese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcdonald, Jr" uniqKey="Mcdonald J">JR McDonald</name></author><author><name sortKey="Zeringue, Al" uniqKey="Zeringue A">AL Zeringue</name></author><author><name sortKey="Caplan, L" uniqKey="Caplan L">L Caplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Strangfeld, A" uniqKey="Strangfeld A">A Strangfeld</name></author><author><name sortKey="Eveslage, M" uniqKey="Eveslage M">M Eveslage</name></author><author><name sortKey="Schneider, M" uniqKey="Schneider M">M Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galloway, Jb" uniqKey="Galloway J">JB Galloway</name></author><author><name sortKey="Hyrich, Kl" uniqKey="Hyrich K">KL Hyrich</name></author><author><name sortKey="Mercer, Lk" uniqKey="Mercer L">LK Mercer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winthrop, Kl" uniqKey="Winthrop K">KL Winthrop</name></author><author><name sortKey="Yamanaka, H" uniqKey="Yamanaka H">H Yamanaka</name></author><author><name sortKey="Valdez, H" uniqKey="Valdez H">H Valdez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paniagua, R" uniqKey="Paniagua R">R Paniagua</name></author><author><name sortKey="Si, Ms" uniqKey="Si M">MS Si</name></author><author><name sortKey="Flores, Mg" uniqKey="Flores M">MG Flores</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abel, L" uniqKey="Abel L">L Abel</name></author><author><name sortKey="El Baghdadi, J" uniqKey="El Baghdadi J">J El-Baghdadi</name></author><author><name sortKey="Bousfiha, Aa" uniqKey="Bousfiha A">AA Bousfiha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maiga, M" uniqKey="Maiga M">M Maiga</name></author><author><name sortKey="Lun, S" uniqKey="Lun S">S Lun</name></author><author><name sortKey="Guo, H" uniqKey="Guo H">H Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malmgaard, L" uniqKey="Malmgaard L">L Malmgaard</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li><li>Espagne</li><li>Japon</li><li>Mexique</li><li>Pérou</li><li>Turquie</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Winthrop, K L" sort="Winthrop, K L" uniqKey="Winthrop K" first="K L" last="Winthrop">K L Winthrop</name></noRegion><name sortKey="Kwok, K" sort="Kwok, K" uniqKey="Kwok K" first="K" last="Kwok">K. Kwok</name><name sortKey="Lukic, T" sort="Lukic, T" uniqKey="Lukic T" first="T" last="Lukic">T. Lukic</name><name sortKey="Mortensen, E" sort="Mortensen, E" uniqKey="Mortensen E" first="E" last="Mortensen">E. Mortensen</name><name sortKey="Riese, R" sort="Riese, R" uniqKey="Riese R" first="R" last="Riese">R. Riese</name><name sortKey="Valdez, H" sort="Valdez, H" uniqKey="Valdez H" first="H" last="Valdez">H. Valdez</name></country><country name="Corée du Sud"><noRegion><name sortKey="Park, S H" sort="Park, S H" uniqKey="Park S" first="S-H" last="Park">S-H Park</name></noRegion></country><country name="Turquie"><noRegion><name sortKey="Gul, A" sort="Gul, A" uniqKey="Gul A" first="A" last="Gul">A. Gul</name></noRegion></country><country name="Mexique"><noRegion><name sortKey="Cardiel, M H" sort="Cardiel, M H" uniqKey="Cardiel M" first="M H" last="Cardiel">M H Cardiel</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Gomez Reino, J J" sort="Gomez Reino, J J" uniqKey="Gomez Reino J" first="J J" last="Gomez-Reino">J J Gomez-Reino</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Tanaka, Y" sort="Tanaka, Y" uniqKey="Tanaka Y" first="Y" last="Tanaka">Y. Tanaka</name></noRegion></country><country name="Pérou"><noRegion><name sortKey="Ponce De Leon, D" sort="Ponce De Leon, D" uniqKey="Ponce De Leon D" first="D" last="Ponce De Leon">D. Ponce De Leon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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